Cialis is a brand name for a substance with the chemical name tadalafil. Medical testing has shown that cialis is effective in 60%-80%, of cases when used to treat erectile dysfunction in men. Medications like cialis, viagra, and levitra work by inhibiting a chemical called phosphodiesterase type 5. Because of their mode of action, these drugs are commonly referred to simply as PDE5 inhibitors. The effects of cialis have been shown to last 24 to 36 hours in a majority of users. Taking cialis does not increase sexual desire and it will not give you an erection for 36 hours. Most men who take cialis report that for up to 36 hours after taking cialis, an erection can be sustained when the penis was stimulated by touch. After orgasm, the penis will usually return to its pre-aroused state.